1 Single Molecule Optics - 2013
نویسنده
چکیده
منابع مشابه
Gold nanoparticles for enhanced single molecule fluorescence analysis at micromolar concentration.
Individual metal nanoparticles represent an inexpensive and versatile platform to enhance the detection of fluorescent species at biologically relevant concentrations. Here we use fluorescence correlation spectroscopy to quantify the near-field detection volume and average fluorescence enhancement factors set by a single gold nanoparticle. We demonstrate detection volumes down to 270 zeptoliter...
متن کاملNoise-equivalent sensitivity of photoacoustics.
The fundamental limitations of photoacoustic microscopy for detecting optically absorbing molecules are investigated both theoretically and experimentally. We experimentally demonstrate noise-equivalent detection sensitivities of 160,000 methylene blue molecules (270 zeptomol or 2.7×10-19 mol) and 86,000 oxygenated hemoglobin molecules (140 zeptomol) using narrowband continuous-wave photoacous...
متن کاملSingular phase nano-optics in plasmonic metamaterials for label-free single-molecule detection.
The non-trivial behaviour of phase is crucial for many important physical phenomena, such as, for example, the Aharonov-Bohm effect and the Berry phase. By manipulating the phase of light one can create 'twisted' photons, vortex knots and dislocations which has led to the emergence of the field of singular optics relying on abrupt phase changes. Here we demonstrate the feasibility of singular v...
متن کاملDirectional Raman scattering from single molecules in the feed gaps of optical antennas.
Controlling light from single emitters is an overarching theme of nano-optics. Antennas are routinely used to modify the angular emission patterns of radio wave sources. "Optical antennas" translate these principles to visible and infrared wavelengths and have been recently used to modify fluorescence from single quantum dots and single molecules. Understanding the properties of single molecule...
متن کاملSingle-molecule orientation measurements with a quadrated pupil.
This Letter presents a means of measuring the dipole orientation of a fluorescent, orientationally fixed single molecule, which uses a specially designed phase mask, termed a "quadrated pupil," conjugate to the back focal plane of a conventional wide-field microscope. The method leverages the spatial anisotropy of the far-field emission pattern of a dipole emitter and makes this anisotropy amen...
متن کامل